Reflections

Notes on AI, evidence, and market access

Expert insights on healthcare AI, HEOR, HTA, and the science of getting therapies to patients faster.

Latest · July 5, 2026Simulating the Committee: How Loon Waters™ Predicts Reimbursement Recommendations — and Their ConditionsThe validation study behind Loon Waters™ asks whether HTA committee deliberation can be simulated — and tests it on 67 CDA-AMC decisions issued after the models' knowledge cut-off. Monte Carlo Committee Simulation predicted recommendations with 93.2% accuracy, forecast the conditions attached to them, and flagged its own uncertainty where it mattered.Mara Rada · 7 min read

From the paper"Validated on 67 real CDA-AMC decisions issued after the models' knowledge cut-off — so every correct call reflects reasoning, not recall. The system knows when to trust itself: 96.8% accuracy on high-mandate calls, dropping to 40% on the weakest — so teams act on the confident predictions and route the less confident ones to expert interpretation."

Pricing · January 5, 2026Navigating Convergent Pricing Headwinds: A Strategic Assessment of Policy Risk and Value Defence in the U.S. Biopharmaceutical MarketMara Rada · 9 min read Policy · August 3, 2025US Pharmaceutical Pricing Ultimatum and the Evolving Drug Value Assessment LandscapeDr. Ghayath Janoudi · 7 min read AI & HTA · July 5, 2025Revolutionizing Health Technology Assessment: How AI is Transforming Market Access in 2024Loon Team · 4 min read AI & HTA · February 8, 2025AI Integration in Health Technology Assessment: Evidence from Early Adopters in 2025Loon Team · 8 min read Biopharma · January 27, 2025Hidden Risks in Biopharma: Clinical and Economic EvidenceMara Rada · 6 min read Market access · December 31, 2024AI Drug Discovery's $60 Billion Reality Check: Hype, Failures, and the Market Access BlindspotMara Rada · 15 min read Compliance · December 10, 2024Loon's Compliance with the NICE Position, CDA-AMC Guidelines, and ISPOR ELEVATE-AI LLMs Framework on The Use of AI in Evidence SynthesisLoon Team · 10 min read Market access · December 5, 2024Systematic Risk Assessment in Pharmaceutical Market Access: An Evidence-Based AnalysisMara Rada · 8 min read Multi-agent AI · September 20, 2024Building the Next Generation of HEOR: Loon's Multi-Agent AI ArchitectureDr. Ghayath Janoudi · 7 min read Keynote · June 15, 2024The 'Why' Behind AI: Keynote from Innovation GatheringDr. Ghayath Janoudi · 8 min read